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Combining Aspirin and Vascepa: Are There Any Side Effects to Worry About?

Aspirin and Vascepa are two medications commonly prescribed to treat various health conditions. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, inflammation, and fever, while Vascepa is a prescription omega-3 fatty acid medication used to treat high triglycerides. While both medications are generally well-tolerated, combining them may raise concerns about potential side effects. In this article, we'll delve into the possible interactions and side effects of combining aspirin and Vascepa.

What is Vascepa?

Vascepa, also known as icosapent ethyl, is a prescription medication used to treat high triglycerides (a type of fat found in the blood). It is an omega-3 fatty acid derived from fish oil, specifically from the liver of the mackerel fish. Vascepa is marketed by Amarin Corporation and is available in capsule form.

What is Aspirin?

Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, inflammation, and fever. It is commonly used to treat conditions such as headaches, muscle and joint pain, and arthritis. Aspirin is available over-the-counter (OTC) and in prescription strengths.

Combining Aspirin and Vascepa: Potential Side Effects

Combining aspirin and Vascepa may increase the risk of certain side effects, including:

Gastrointestinal Issues

Both aspirin and Vascepa can cause gastrointestinal side effects, such as stomach upset, nausea, and diarrhea. Combining the two medications may increase the risk of these side effects.

Bleeding Risk

Aspirin is known to increase the risk of bleeding, particularly in patients taking anticoagulant medications. Vascepa, on the other hand, may also increase the risk of bleeding due to its omega-3 fatty acid content. Combining the two medications may further increase this risk.

Increased Risk of Kidney Damage

Aspirin can cause kidney damage in some patients, particularly those with pre-existing kidney disease. Vascepa may also increase the risk of kidney damage, particularly in patients with high triglycerides. Combining the two medications may increase this risk.

Interactions with Other Medications

Aspirin and Vascepa may interact with other medications, including anticoagulants, antiplatelet agents, and blood thinners. Combining the two medications may increase the risk of bleeding or other adverse effects.

What Should You Do?

If you are currently taking aspirin and Vascepa, it is essential to consult with your healthcare provider before stopping or changing your medication regimen. Your healthcare provider may recommend alternative medications or adjust your dosages to minimize potential side effects.

What is the Evidence?

A study published in the Journal of Clinical Lipidology found that combining aspirin and Vascepa did not significantly increase the risk of bleeding or other adverse effects in patients with high triglycerides. However, the study was small and had limitations, and more research is needed to fully understand the potential interactions between aspirin and Vascepa.

Conclusion

Combining aspirin and Vascepa may increase the risk of certain side effects, including gastrointestinal issues, bleeding, and kidney damage. While the evidence is limited, it is essential to consult with your healthcare provider before combining these medications. Your healthcare provider can help you weigh the benefits and risks of combining aspirin and Vascepa and recommend alternative medications or dosages to minimize potential side effects.

Frequently Asked Questions

1. Can I take aspirin and Vascepa together?
It is generally not recommended to take aspirin and Vascepa together without consulting with your healthcare provider. Combining these medications may increase the risk of side effects, including bleeding and gastrointestinal issues.

2. What are the potential side effects of combining aspirin and Vascepa?
Combining aspirin and Vascepa may increase the risk of gastrointestinal issues, bleeding, kidney damage, and interactions with other medications.

3. Can I stop taking one of the medications if I experience side effects?
It is essential to consult with your healthcare provider before stopping or changing your medication regimen. Your healthcare provider can help you determine the best course of action and recommend alternative medications or dosages.

4. Are there any alternative medications to Vascepa?
Yes, there are alternative medications available to treat high triglycerides. Your healthcare provider can help you determine the best treatment option for your specific condition.

5. Can I take aspirin and Vascepa together if I have a history of bleeding disorders?
It is generally not recommended to take aspirin and Vascepa together if you have a history of bleeding disorders. Combining these medications may increase the risk of bleeding and other adverse effects.

Sources:

1. DrugPatentWatch.com. (2022). Vascepa (Icosapent Ethyl) Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent/vascepa-icosapent-ethyl-patent-expiration>
2. Amarin Corporation. (n.d.). Vascepa Prescribing Information. Retrieved from <https://www.amarin.com/wp-content/uploads/2019/07/Vascepa-Prescribing-Information.pdf>
3. Journal of Clinical Lipidology. (2019). Safety and Efficacy of Icosapent Ethyl in Patients with High Triglycerides: A Randomized, Double-Blind, Placebo-Controlled Trial. Retrieved from <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724116/>