See the DrugPatentWatch profile for lipitor

Based on the available information, there is no specific mention of drugs that negatively combine with Lipitor (atorvastatin) in the liver. However, it is well-known that certain drugs can interact with Lipitor, potentially leading to increased risk of side effects or reduced effectiveness of one or both of the drugs. It is always recommended to consult with a healthcare professional or pharmacist before combining any medications.

That being said, there is a known interaction between Lipitor and grapefruit juice that can affect the liver. According to the FDA, consuming grapefruit juice in large quantities while taking Lipitor can increase the amount of atorvastatin in the body, which can lead to liver damage or other side effects [3]. Therefore, it is advisable to avoid consuming large amounts of grapefruit juice while taking Lipitor.

In general, Lipitor can cause side effects related to the liver, including increased liver enzymes and liver damage, although these are rare [1][2]. Patients should consult their healthcare provider if they experience symptoms such as yellowing of the skin or eyes, dark-colored urine, or abdominal pain, as these may indicate liver problems.

In summary, while there is no specific information on drugs that negatively combine with Lipitor in the liver, it is important to be aware of the potential interaction between Lipitor and grapefruit juice. Patients should also be mindful of any liver-related side effects and consult their healthcare provider if they have concerns.

Sources:

1. <https://www.drugpatentwatch.com/p/tradename/LIPITOR>
2. <https://www.medicalnewstoday.com/articles/drugs-lipitor-side-effects>
3. <https://www.fda.gov/consumers/consumer-updates/grapefruit-juice-and-some-drugs-dont-mix>