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Lipitor, a statin medication used to lower cholesterol levels, is not generally affected by high-fat diets in terms of its efficacy [1]. However, it is important to note that high-fat diets can increase the risk of cardiovascular disease, which is the very condition Lipitor is often prescribed to manage.

Lipitor works by inhibiting the HMG-CoA reductase enzyme, which plays a crucial role in the production of cholesterol in the body. This mechanism is independent of dietary fat intake [1].

However, high-fat diets, particularly those high in saturated and trans fats, can exacerbate the risk of cardiovascular disease by increasing low-density lipoprotein (LDL), or "bad" cholesterol levels [2]. This could potentially offset the benefits of Lipitor, as the medication's primary function is to lower LDL cholesterol levels.

In terms of side effects, Lipitor can cause muscle pain and liver damage, although these are rare [1]. High-fat diets, particularly those high in saturated fats, can increase the risk of these side effects [3]. Therefore, it is recommended that Lipitor be used in conjunction with a heart-healthy diet, as advised by a healthcare professional.

Sources:
[1] "Lipitor." Drugs.com, www.drugs.com/lipitor.html.
[2] "Dietary Fats." American Heart Association, 18 Feb. 2015, www.heart.org/en/healthy-living/healthy-eating/eat-smart/fats/dietary-fats.
[3] "Lipitor Side Effects." RxList, www.rxlist.com/lipitor-side-effects-drug-center.htm.