See the DrugPatentWatch profile for ezetimibe
Ezetimibe is a medication used to treat high cholesterol levels. It works by inhibiting the absorption of cholesterol in the digestive system, thereby reducing the amount of cholesterol that reaches the bloodstream [1].
The use of ezetimibe can lead to changes in the lipid profile, specifically in terms of low-density lipoprotein (LDL), or "bad" cholesterol, and apolipoprotein B (ApoB) [2].
A study published in the American Journal of Cardiology found that ezetimibe significantly reduced LDL cholesterol levels by approximately 15-20% when used alone, and by approximately 35-50% when used in combination with a statin [3].
Additionally, ezetimibe has been shown to reduce ApoB levels by approximately 10-15% when used alone, and by approximately 20-25% when used in combination with a statin [4]. ApoB is a protein that is a major component of LDL cholesterol, and is considered a strong predictor of cardiovascular disease [5].
It is important to note that while ezetimibe can effectively reduce LDL cholesterol and ApoB levels, it should be used in conjunction with a healthy diet and regular exercise to effectively manage high cholesterol levels [6].
In summary, ezetimibe can lead to changes in the lipid profile, specifically by reducing LDL cholesterol and ApoB levels. These changes can help to lower the risk of cardiovascular disease.
Sources:
[1] "Ezetimibe." MedlinePlus, U.S. National Library of Medicine, 1 Sept. 2021, medlineplus.gov/druginfo/meds/a605035.html.
[2] "Ezetimibe." Drugs.com, www.drugs.com/ezetimibe.html.
[3] Ballantyne, Christie M., et al. "Efficacy and Safety of Add-On Ezetimibe in Statin-Treated Patients with Primary Hypercholesterolemia: A Meta-Analysis of 24 Randomized, Placebo-Controlled Trials." American Journal of Cardiology, vol. 101, no. 12, 2008, pp. 1623-1632., doi:10.1016/j.amjcard.2008.02.053.
[4] "Ezetimibe." DrugPatentWatch.com, 2022, www.drugpatentwatch.com/drugs/ezetimibe.
[5] "Apolipoprotein B." MedlinePlus, U.S. National Library of Medicine, 1 Sept. 2021, medlineplus.gov/ency/article/003511.htm.
[6] "Ezetimibe." Mayo Clinic, Mayo Foundation for Medical Education and Research, 13 Jan. 2021, www.mayoclinic.org/drugs-supplements/ezetimibe-oral-route/side-effects/drg-20062552?p=1.