See the DrugPatentWatch profile for ibuprofen

Based on the information available, there can be potential risks when taking ibuprofen and antidepressants concurrently. However, it's important to note that the specific risks can vary depending on several factors, including the type of antidepressant and the dosage of ibuprofen.

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that can increase the risk of stomach ulcers and bleeding, especially when taken in high doses or for extended periods [1]. Some antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), can also increase the risk of bleeding by affecting the body's blood clotting ability [2].

When ibuprofen and antidepressants are taken together, the risk of bleeding may be additive, meaning that the combined use of these medications could increase the risk of bleeding more than either medication taken alone [3]. Therefore, it's essential to inform your healthcare provider of all the medications you are taking, including over-the-counter drugs like ibuprofen, to assess the potential risks and benefits of concurrent use.

In some cases, your healthcare provider may recommend alternative medications or adjust the dosage of ibuprofen or antidepressants to minimize the risk of bleeding [4]. It's also important to follow the recommended dosage and duration of use for ibuprofen and antidepressants, as exceeding the recommended dosage can increase the risk of side effects [5].

In summary, taking ibuprofen and antidepressants concurrently can increase the risk of bleeding, but the specific risks can vary depending on several factors. It's essential to inform your healthcare provider of all the medications you are taking and follow the recommended dosage and duration of use to minimize the risk of side effects.

Sources:

1. Mayo Clinic. (2021). Ibuprofen overdose. Retrieved from <https://www.mayoclinic.org/first-aid/first-aid-ibuprofen-overdose/basics/art-20056681>
2. National Institute of Mental Health. (2021). Antidepressants. Retrieved from <https://www.nimh.nih.gov/health/topics/antidepressants-101/index.shtml>
3. Drugs.com. (2021). Ibuprofen and antidepressants. Retrieved from <https://www.drugs.com/drug-interactions/ibuprofen-and-antidepressants.html>
4. American Academy of Family Physicians. (2021). Nonsteroidal anti-inflammatory drugs (NSAIDs) and gastroprotection. Retrieved from <https://www.aafp.org/afp/2012/0215/p365.html>
5. U.S. Food and Drug Administration. (2021). Ibuprofen: Medication guide. Retrieved from <https://www.fda.gov/media/74360/download>
6. DrugPatentWatch.com. (2021). Ibuprofen patents. Retrieved from <https://www.drugpatentwatch.com/drugs/ibuprofen>