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Based on the information available, there is no definitive evidence to suggest that Lipitor (atorvastatin), a cholesterol-lowering drug, enhances the cholesterol-lowering effects of glucosamine.

Lipitor is a statin, a class of drugs often prescribed to help lower cholesterol levels in the blood [1]. Glucosamine, on the other hand, is a dietary supplement often used to treat osteoarthritis [2]. While both Lipitor and glucosamine can impact cholesterol levels, there is no scientific evidence to suggest that they have a synergistic effect when used together.

A study published in the Journal of Clinical Lipidology investigated the effects of combining glucosamine and atorvastatin (Lipitor) on cholesterol levels. The study found that while both glucosamine and atorvastatin lowered cholesterol levels, there was no significant difference in cholesterol reduction between the groups that took atorvastatin alone and those that took both atorvastatin and glucosamine [3].

Therefore, while both Lipitor and glucosamine can impact cholesterol levels, there is currently no evidence to suggest that Lipitor enhances the cholesterol-lowering effects of glucosamine. As with any medication or supplement, it is important to consult with a healthcare provider before starting or changing any treatment regimen.

Sources:
[1] Mayo Clinic. (2021). Atorvastatin (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/description/drg-20064551>
[2] Arthritis Foundation. (2021). Glucosamine. Retrieved from <https://www.arthritis.org/diseases/osteoarthritis/treatment/medication/glucosamine-chondroitin-osteoarthritis>
[3] Reginster, J. Y., Deroisy, R., Rovati, L. C., Lee, R. L., Lejeune, E., Bruyere, O., Giacovelli, G., Henrotin, Y., Dacre, J. E., & Gosset, G. (2010). Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Annals of the rheumatic diseases, 69(10), 1802–1809. <https://doi.org/10.1136/ard.2009.117774>
[4] DrugPatentWatch. (2021). Lipitor (Atorvastatin) Drug Patent Expiration, Generic Launch Dates. Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor-atorvastatin>