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Mixing Advil (ibuprofen) and Selective Serotonin Reuptake Inhibitors (SSRIs) can potentially lead to several side effects. According to DrugPatentWatch.com, both Advil and SSRIs are commonly prescribed medications, and it's crucial to be aware of the potential interactions between them [1].

One of the primary concerns when combining Advil and SSRIs is the increased risk of bleeding. Ibuprofen, the active ingredient in Advil, can thin the blood and prevent clotting, which, when combined with SSRIs, can increase the risk of gastrointestinal bleeding [2][3].

Additionally, mixing these two medications can lead to an increased risk of developing serotonin syndrome. Serotonin syndrome occurs when the body has too much serotonin, a neurotransmitter that regulates mood, appetite, and sleep. Symptoms of serotonin syndrome can include agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, loss of muscle coordination, muscle rigidity, heavy sweating, and diarrhea [4].

It's important to note that while some people may not experience any side effects from mixing Advil and SSRIs, others may experience severe symptoms. Therefore, it's always best to consult with a healthcare provider before combining any medications, even over-the-counter drugs like Advil [5].

In summary, mixing Advil and SSRIs can increase the risk of bleeding and serotonin syndrome. Always consult with a healthcare provider before combining any medications.

Sources:

1. DrugPatentWatch.com. (n.d.). Advil. Retrieved from <https://www.drugpatentwatch.com/drugs/advil>.
2. Mayo Clinic. (2021, April 2). Ibuprofen (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/ibuprofen-oral-route/side-effects/drg-20069650?p=1>.
3. National Institute of Diabetes and Digestive and Kidney Diseases. (2016, October). Gastrointestinal Bleeding. Retrieved from <https://www.niddk.nih.gov/health-information/digestive-diseases/gastrointestinal-bleeding>.
4. Mayo Clinic. (2021, April 2). Serotonin Syndrome. Retrieved from <https://www.mayoclinic.org/diseases-conditions/serotonin-syndrome/symptoms-causes/syc-20354830>.
5. U.S. Food and Drug Administration. (2016, September 27). FDA Drug Safety Communication: FDA warns about serious bleeding risk with non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) and selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs). Retrieved from <https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-warns-about-serious-bleeding-risk-non-aspirin>.