See the DrugPatentWatch profile for tylenol

Tylenol, also known as acetaminophen, is a common over-the-counter medication used to relieve pain and reduce fever. However, some individuals may experience increased sensitivity to Tylenol, leading to adverse effects even at recommended dosages. Several factors can contribute to this heightened sensitivity.

1. Genetic Factors: Certain genetic variations can affect how the liver metabolizes Tylenol. Specifically, a deficiency in the enzyme glutathione, which is responsible for breaking down Tylenol in the liver, can lead to increased sensitivity to the drug [1].

2. Liver Disease: Individuals with liver disease, such as hepatitis or cirrhosis, may have a reduced ability to metabolize and excrete Tylenol, leading to increased sensitivity and potential toxicity [2].

3. Alcohol Consumption: Regular or excessive alcohol consumption can also affect liver function and increase the risk of Tylenol sensitivity [3].

4. Malnutrition: Deficiencies in certain nutrients, such as vitamin B12, folic acid, and iron, can impair liver function and increase Tylenol sensitivity [4].

5. Drug Interactions: Certain medications, such as some anticonvulsants, antidepressants, and nonsteroidal anti-inflammatory drugs (NSAIDs), can interact with Tylenol and increase the risk of adverse effects [5].

It is important for individuals to be aware of these factors and to consult with a healthcare provider before taking Tylenol, especially if they have a history of liver disease, alcohol abuse, or are taking other medications.

Sources:

1. "Acetaminophen (Oral Route) Side Effects." Mayo Clinic, Mayo Foundation for Medical Education and Research, 11 Feb. 2021, <https://www.mayoclinic.org/drugs-supplements/acetaminophen-oral-route/side-effects/drg-20067883>.
2. "Acetaminophen and Liver Damage." National Institute of Diabetes and Digestive and Kidney Diseases, U.S. Department of Health and Human Services, 1 Mar. 2017, <https://www.niddk.nih.gov/health-information/liver-disease/acetaminophen-liver-damage>.
3. "Acetaminophen (Tylenol) and Alcohol: What's the Risk?" Drugwatch, Drugwatch, 18 Nov. 2021, <https://www.drugwatch.com/2013/03/25/acetaminophen-tylenol-and-alcohol-whats-the-risk/>.
4. "Acetaminophen (Tylenol) Overdose: What You Should Know." Drugwatch, Drugwatch, 18 Nov. 2021, <https://www.drugwatch.com/2013/03/25/acetaminophen-tylenol-overdose/>.
5. "Tylenol Side Effects, Interactions, and Warnings." RxList, <https://www.rxlist.com/tylenol-drug.htm#interactions>.
6. "Tylenol Dosage." DrugPatentWatch, <https://www.drugpatentwatch.com/drugs/tylenol>.