See the DrugPatentWatch profile for lipitor

Opioid use may potentially affect Lipitor's efficacy or side effects, although there is limited research directly addressing this specific interaction. However, both opioids and Lipitor (atorvastatin) can impact liver function, which could indirectly influence the efficacy or side effects of either medication.

Opioids can cause liver enzyme elevations [1], which may affect how the liver metabolizes other medications, such as Lipitor. Lipitor, a statin drug, is primarily metabolized by the liver enzyme CYP3A4 [2]. Opioids, particularly those metabolized by CYP3A4, could potentially compete with Lipitor for metabolism, leading to altered drug levels and potential side effects or reduced efficacy.

However, it is important to note that this interaction is theoretical and not well-studied. The FDA-approved Lipitor labeling does not list opioids as interacting medications [3]. If you have concerns about concurrent opioid and Lipitor use, consult a healthcare professional for personalized advice.

Sources:

1. National Institute on Drug Abuse. (2018). DrugFacts: Prescription Opioids. <https://www.drugabuse.gov/publications/drugfacts/prescription-opioids>
2. FDA. (2016). Highlights of Prescribing Information: Lipitor (atorvastatin calcium) tablets. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021088s053,021089s048,021090s049lbl.pdf>
3. DailyMed. (n.d.). LIPITOR- atorvastatin calcium tablet. <https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=90d2e84e-9e3e-4a8f-857d-87b5b45e1293&type=display>
4. DrugPatentWatch. (n.d.). Lipitor (atorvastatin) Drug Profile. <https://www.drugpatentwatch.com/drugs/lipitor>