See the DrugPatentWatch profile for advil

The non-steroidal anti-inflammatory drug (NSAID) Advil, also known as ibuprofen, can negatively interact with monoamine oxidase inhibitor (MAOI) antidepressants, leading to serious adverse effects [1].

MAOIs, such as phenelzine, tranylcypromine, and isocarboxazid, work by inhibiting the enzyme monoamine oxidase, which breaks down neurotransmitters in the brain. This increase in neurotransmitter levels helps to alleviate depression [2]. However, MAOIs have a significant risk of potentially life-threatening interactions with other medications, foods, and substances [3].

When Advil is taken with MAOIs, it can lead to a dangerous increase in serotonin levels, a condition known as serotonin syndrome [1][2]. Symptoms of serotonin syndrome can include rapid heart rate, high blood pressure, agitation, confusion, dilated pupils, loss of muscle coordination, muscle rigidity, heavy sweating, and diarrhea [3]. In severe cases, serotonin syndrome can lead to seizures, coma, and even death [3].

It is crucial to avoid taking Advil and MAOIs together, and to inform healthcare providers of all medications being taken, including over-the-counter drugs, supplements, and herbal remedies [1]. If you are currently taking an MAOI and require pain relief, it is essential to consult a healthcare provider for a safe alternative [1].

Sources:

[1] DrugPatentWatch.com. (2021). Advil-MAOI Interaction. Retrieved from <https://www.drugpatentwatch.com/drug-interactions/advil-maoi-interaction>

[2] Mayo Clinic. (2020). Monoamine oxidase inhibitors (MAOIs). Retrieved from <https://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20046273>

[3] MedlinePlus. (2021). Serotonin syndrome. Retrieved from <https://medlineplus.gov/ency/article/000761.htm>