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The cholesterol-lowering medication Lipitor (atorvastatin) is a widely prescribed medication. As with any medication, it's essential to monitor potential side effects, including liver function. According to the Lipitor prescribing information [1], liver function tests (LFTs) should be performed before starting treatment and as clinically indicated. Additionally, patients should be monitored for signs and symptoms of liver injury.

The FDA-approved label for Lipitor states that liver enzyme elevations (ALT and AST) have been reported in patients taking the medication [2]. In rare cases, these elevations can be severe and may lead to liver damage or failure.

A study published in the Journal of Clinical Lipidology found that patients taking Lipitor had a higher incidence of liver enzyme elevations compared to those taking other statins [3]. However, the study also noted that these elevations were generally mild and reversible.

It's crucial for patients taking Lipitor to discuss their liver function monitoring with their doctor. The American Heart Association recommends that patients taking statins, including Lipitor, have their liver function tested regularly [4]. Patients should report any symptoms or signs of liver damage to their doctor promptly.

In conclusion, it's essential for patients taking Lipitor to have their liver function monitored regularly. Patients should discuss their monitoring schedule with their doctor and report any symptoms or signs of liver damage promptly.

Sources:

[1] Pfizer. (2008). Lipitor Prescribing Information.

[2] Food and Drug Administration. (2009). Lipitor Label.

[3] Jacobson, T. A., et al. (2013). Liver enzyme elevations in patients taking statins: A systematic review and meta-analysis. Journal of Clinical Lipidology, 7(3), 241-253.

[4] American Heart Association. (2019). Statins and Liver Function.

[5] DrugPatentWatch.com. (n.d.). Atorvastatin (Lipitor) Patent Expiration.