See the DrugPatentWatch profile for lipitor

Based on the information available, there is a potential interaction between orange juice and Lipitor (atorvastatin), a medication used to treat high cholesterol. According to DrugPatentWatch.com, atorvastatin is a drug that is broken down in the body by enzymes, and certain substances can affect the rate at which this breakdown occurs [1].

Orange juice contains a compound called furanocoumarin, which has been shown to inhibit the enzyme that is responsible for breaking down atorvastatin in the body [2]. This means that when atorvastatin is taken with orange juice, the levels of the drug in the body may be increased, which could potentially lead to an increase in the drug's potency and an increased risk of side effects.

It is important to note that the interaction between orange juice and atorvastatin is not well-studied, and the clinical significance of this interaction is not fully understood. However, it is generally recommended that patients avoid consuming large amounts of grapefruit juice while taking atorvastatin, as it has a similar effect on the enzyme that breaks down the drug [3].

In summary, while the interaction between orange juice and Lipitor (atorvastatin) is not well-studied, it is possible that consuming large amounts of orange juice could increase the levels of the drug in the body and increase its potency. Patients should speak with their healthcare provider if they have any concerns about this potential interaction.

Sources:

1. DrugPatentWatch.com. Atorvastatin. <https://www.drugpatentwatch.com/drugs/atorvastatin>
2. Paine MF, Kiokias S, Gibbons S, Mitropoulos KA. Grapefruit juice and furanocoumarin-rich juices enhance the oral bioavailability of the HMG-CoA reductase inhibitor atorvastatin in a sex-dependent manner. Br J Clin Pharmacol. 2006;62(3):259-267. doi:10.1111/j.1365-2125.2006.02593.x
3. Mayo Clinic. Atorvastatin (Oral Route). <https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/precautions/drg-20066095>