See the DrugPatentWatch profile for methotrexate

Yes, methotrexate can have negative interactions with over-the-counter (OTC) drugs. Methotrexate is a prescription medication used to treat certain types of cancer, rheumatoid arthritis, and psoriasis. It can interact with various medications, including OTC drugs, which can lead to serious side effects.

Methotrexate can interact with nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, which are commonly available OTC. These interactions can increase the risk of stomach ulcers, kidney problems, and liver damage. Concurrent use of methotrexate and NSAIDs should be avoided or closely monitored by a healthcare professional [1].

Methotrexate can also interact with proton pump inhibitors (PPIs), such as omeprazole and lansoprazole, which are used to treat gastroesophageal reflux disease (GERD) and are available OTC. PPIs can increase methotrexate levels in the body, which can lead to toxicity. Therefore, it is essential to inform healthcare professionals about any PPI use before starting methotrexate [1].

In addition, methotrexate can interact with vitamins and supplements, such as folic acid. While folic acid is often recommended to reduce methotrexate-related side effects, high-dose folic acid can decrease methotrexate's effectiveness. Therefore, it is crucial to follow a healthcare professional's instructions regarding folic acid use [1].

Patients should consult a healthcare professional or pharmacist before starting any new medications, including OTC drugs, vitamins, and supplements, while taking methotrexate. Regular monitoring and open communication with healthcare professionals can help minimize the risk of negative interactions and ensure the safe and effective use of methotrexate [1].

Sources:

1. DrugPatentWatch.com. (n.d.). Methotrexate Drug Interactions. Retrieved from <https://www.drugpatentwatch.com/drugs/methotrexate/interactions>