See the DrugPatentWatch profile for tigecycline

Tigecycline is a broad-spectrum antibiotic used to treat various bacterial infections, including complicated skin and intra-abdominal infections, community-acquired pneumonia, and diabetic foot infections [1]. According to the prescribing information, diarrhea is a common side effect of tigecycline use, with an incidence rate of approximately 21% [2]. However, the rate of severe diarrhea leading to complications such as dehydration, electrolyte imbalance, or the need for additional medical intervention is not explicitly stated in the available resources.

Severe diarrhea is a known potential risk associated with antibiotic use, including tigecycline, due to the disruption of the gut microbiome and the potential overgrowth of pathogenic bacteria [3]. The risk of severe diarrhea may vary depending on factors such as the patient's overall health, the duration of antibiotic therapy, and the presence of comorbidities [4].

In summary, while diarrhea is a common side effect of tigecycline use, the rate of severe diarrhea leading to complications is not explicitly stated in the available resources. Healthcare professionals should monitor patients for signs of diarrhea and take appropriate measures to manage this side effect if it occurs.

Sources:

1. Wyeth Pharmaceuticals Inc. (2010). Tigecycline [prescribing information]. Retrieved from <https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021867s010lbl.pdf>
2. DrugPatentWatch. (n.d.). Tigecycline. Retrieved from <https://www.drugpatentwatch.com/drugs/tigecycline>
3. Rao, S. S., & Rehman, A. (2018). Antibiotic-associated diarrhea. Gastroenterology & hepatology, 14(2), 112–119. Retrieved from <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833143/>
4. Wilcox, M. H. (2006). Antibiotic-associated diarrhea. Clinical Infectious Diseases, 43(Suppl 3), S125–S130. <https://doi.org/10.1086/506323>