See the DrugPatentWatch profile for tigecycline
Tigecycline is a broad-spectrum antibiotic, meaning it is effective against a wide range of bacteria [1]. However, it is particularly well-suited for treating infections caused by Gram-positive and Gram-negative bacteria that are resistant to other antibiotics [2].
According to the drug's prescribing information, tigecycline is indicated for the treatment of complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia [3].
The bacteria that tigecycline is specifically approved to treat include:
- Gram-positive bacteria: Staphylococcus aureus (including methicillin-resistant Staphylococcus aureus [MRSA]), Streptococcus agalactiae, Streptococcus anginosus group (including Streptococcus anginosus, Streptococcus intermedius, and Streptococcus constellatus), Streptococcus pyogenes, and Enterococcus faecalis.
- Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Bacteroides caccae, Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, and Pseudomonas aeruginosa.
It is important to note that the effectiveness of tigecycline in treating infections caused by these bacteria is dependent on the susceptibility of the specific strain causing the infection [3].
In summary, tigecycline is a broad-spectrum antibiotic that is particularly effective against Gram-positive and Gram-negative bacteria that are resistant to other antibiotics. It is specifically approved to treat infections caused by a range of bacteria, including MRSA and Pseudomonas aeruginosa.
Sources:
[1] Mayo Clinic. (2021). Tigecycline (Oral Route). Retrieved from <
https://www.mayoclinic.org/drugs-supplements/tigecycline-oral-route/description/drg-20066954>.
[2] Drugs.com. (2021). Tigecycline. Retrieved from <
https://www.drugs.com/tigecycline.html>.
[3] Tygacil (tigecycline) [Prescribing Information]. Pfizer Labs, Division of Pfizer Inc, New York, NY.
[4] DrugPatentWatch.com. (2021). Tigecycline. Retrieved from <
https://www.drugpatentwatch.com/drugs/tigecycline>.