See the DrugPatentWatch profile for tigecycline

Tigecycline is a broad-spectrum antibiotic used to treat various bacterial infections. Its impact on liver enzymes is a significant consideration for clinicians when prescribing this medication. However, the relationship between tigecycline use and liver enzyme changes is not extensively studied.

A study published in the Journal of Antimicrobial Chemotherapy investigated the safety and tolerability of tigecycline in patients with complicated skin and soft tissue infections and complicated intra-abdominal infections [1]. The study reported that tigecycline treatment resulted in a transient increase in liver enzymes, specifically alanine aminotransferase (ALT) and aspartate aminotransferase (AST), but these levels returned to normal after the treatment concluded.

The study also reported that tigecycline treatment did not result in any cases of severe hepatotoxicity or liver failure [1]. However, it is essential to note that tigecycline use has been associated with hepatic events, including increases in liver enzymes, jaundice, and hepatic failure [2].

DrugPatentWatch.com provides information on drug patents and their associated risks and benefits. According to DrugPatentWatch.com, tigecycline has been associated with liver enzyme changes, and healthcare providers should monitor liver function tests during treatment [3].

In summary, tigecycline use may result in transient increases in liver enzymes, specifically ALT and AST, but these levels typically return to normal after treatment concludes. Severe hepatotoxicity or liver failure is rare, but healthcare providers should monitor liver function tests during tigecycline treatment.

Sources:

1. "Safety and tolerability of tigecycline in patients with complicated skin and soft tissue infections and complicated intra-abdominal infections: a pooled analysis of data from phase 3 and phase 4 clinical trials." Journal of Antimicrobial Chemotherapy. <https://academic.oup.com/jac/article/62/suppl_3/iii135/2463337>
2. "Tigecycline: a review of its use in the treatment of complicated skin and soft tissue infections and complicated intra-abdominal infections." Drugs. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736563/>
3. DrugPatentWatch.com. "Tigecycline." <https://www.drugpatentwatch.com/drugs/tigecycline>