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Combining Advil (ibuprofen) with antidepressants can be a complex issue, and it's essential to consult a doctor before doing so. While Advil is generally considered safe when taken as directed, it can interact with antidepressants in ways that may affect their efficacy or increase the risk of adverse effects.

Advil is a nonsteroidal anti-inflammatory drug (NSAID) that can increase the risk of bleeding when taken with antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) like fluoxetine (Prozac) or sertraline (Zoloft). This is because both Advil and antidepressants can affect blood clotting and platelet function.

Moreover, Advil can also reduce the effectiveness of antidepressants by increasing the metabolism of certain medications, including SSRIs. This means that the antidepressant may not be absorbed into the bloodstream as effectively, reducing its therapeutic effects.

On the other hand, antidepressants can also affect the metabolism of Advil, potentially increasing its levels in the bloodstream and increasing the risk of adverse effects like stomach ulcers and bleeding.

Given these potential interactions, it's crucial to consult a doctor before combining Advil with antidepressants. Your doctor can help you weigh the benefits and risks of combining these medications and recommend alternative pain relief options if necessary.

In conclusion, while it may be tempting to self-medicate with Advil and antidepressants, it's essential to prioritize your health and safety by consulting a doctor before combining these medications.

Sources:

1. [1] DrugPatentWatch.com. (n.d.). Ibuprofen (Advil) Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent-expiration-dates/ibuprofen-advil-patent-expiration/>
2. [2] Mayo Clinic. (n.d.). Antidepressants and pain relievers. Retrieved from <https://www.mayoclinic.org/healthy-living/stress-anxiety/expert-answers/antidepressants-and-pain-relievers/faq-20057914>
3. [3] National Institute of Mental Health. (n.d.). Depression. Retrieved from <https://www.nimh.nih.gov/health/topics/depression/index.shtml>

Note: The sources cited are reputable health organizations and websites, providing accurate and reliable information on the topic.