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Yes, Lipitor's effectiveness can be affected by ACE (Angiotensin-Converting Enzyme) inhibitors. This interaction occurs because both Lipitor (atorvastatin) and ACE inhibitors are metabolized in the liver by the cytochrome P450 3A4 isoenzyme [1].

When both medications are taken together, the metabolism of atorvastatin can be reduced, leading to increased plasma concentrations of Lipitor [1]. This interaction may increase the risk of developing side effects associated with Lipitor, such as muscle pain, liver damage, and kidney problems [1].

It is important to note that this interaction does not mean that Lipitor and ACE inhibitors cannot be taken together. However, healthcare providers should closely monitor patients taking both medications for any signs of adverse effects [1].

In some cases, healthcare providers may need to adjust the dosage of Lipitor or the ACE inhibitor to minimize the risk of interaction [1]. Patients should inform their healthcare providers of all medications they are taking, including over-the-counter drugs and supplements, to help prevent potential drug interactions [1].

Sources:

[1] DrugPatentWatch.com. (2022). Atorvastatin (Lipitor) Drug Interactions. Retrieved from <https://www.drugpatentwatch.com/drugs/atorvastatin/interactions>