See the DrugPatentWatch profile for lyrica

When Lyrica (pregabalin) and opioids are taken together, several interactions can occur. It is important to note that both Lyrica and opioids can cause central nervous system depression, and when used together, the risk of this side effect may be increased [1].

Lyrica is an anticonvulsant medication used to treat seizures, fibromyalgia, and neuropathic pain [1]. Opioids, on the other hand, are a class of drugs used to treat pain, cough, and diarrhea [2].

When Lyrica and opioids are taken together, the risk of respiratory depression, sedation, and dizziness may be increased [1]. This is because both drugs act on the central nervous system and can cause similar side effects.

Additionally, Lyrica may increase the levels of opioids in the body [1]. This is because Lyrica can inhibit certain enzymes in the body that are responsible for breaking down opioids, leading to an increase in opioid levels in the body [1]. This can increase the risk of opioid-related side effects, such as respiratory depression, sedation, and dizziness.

It is important to note that the use of Lyrica and opioids together may also increase the risk of addiction and dependence [1]. This is because both drugs can cause euphoria and a sense of well-being, which can lead to addiction and dependence.

In conclusion, when Lyrica and opioids are taken together, the risk of respiratory depression, sedation, dizziness, and addiction may be increased. It is important to speak with a healthcare provider before taking these medications together.

Sources:
[1] <https://www.drugpatentwatch.com/drugs/lyrica>
[2] <https://medlineplus.gov/opioidmisuse.html>