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Based on the information available, it is generally considered safe to take Lipitor (atorvastatin), a medication used to treat high cholesterol, with SSRI (Selective Serotonin Reuptake Inhibitor) antidepressants, such as Prozac (fluoxetine), Zoloft (sertraline), or Lexapro (escitalopram) [1]. However, as with any medication combination, there is a potential for drug interactions [1].

The drug interaction between Lipitor and SSRIs is not expected to be significant, but it is still important for healthcare providers to be aware of this potential interaction [2]. The most common interaction between Lipitor and SSRIs is an increase in the blood levels of both medications, which could increase the risk of side effects [1].

It is always recommended to inform your healthcare provider of all medications, supplements, and herbal products you are taking, as they can provide personalized advice based on your medical history and current health status [1].

In summary, while it is generally considered safe to take Lipitor with SSRI antidepressants, it is essential to consult with a healthcare provider to ensure the safe and effective use of these medications [1].

Sources:
[1] <https://www.drugs.com/drug-interactions/atorvastatin-with-fluoxetine-372-1313-1571-0-131331.html>
[2] <https://www.drugpatentwatch.com/drugs/lipitor>