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Yes, long-term use of acetaminophen can lead to liver damage. Acetaminophen, also known as paracetamol, is a common over-the-counter medication used for pain relief and reducing fever. However, when taken in excessive amounts or for prolonged periods, it can result in liver injury or failure [1].

Acetaminophen is primarily metabolized in the liver, and long-term use can cause toxicity, especially when consumed in larger doses or in combination with alcohol [1][2]. The risk of liver damage increases with the frequency and duration of use, as well as the amount taken at one time [1].

Symptoms of acetaminophen-induced liver damage may include loss of appetite, nausea, vomiting, stomach pain, and fatigue [1]. In severe cases, it can lead to jaundice, liver failure, and even death [1].

It is essential to follow the recommended dosage and consult a healthcare professional before using acetaminophen for an extended period or in high doses [1]. Regular monitoring of liver function may also be necessary for those at risk of liver damage due to acetaminophen use [1].

In summary, long-term acetaminophen use can lead to liver damage, and it is crucial to follow dosage instructions and consult a healthcare professional to minimize the risk of liver injury [1][2].

Sources:
[1] U.S. National Library of Medicine. (2021). Acetaminophen. MedlinePlus. <https://medlineplus.gov/druginfo/meds/a681001.html>
[2] DrugPatentWatch. (2021). Acetaminophen. DrugPatentWatch. <https://www.drugpatentwatch.com/drugs/acetaminophen>