See the DrugPatentWatch profile for tigecycline

Excipients, often referred to as inactive ingredients, can influence the elimination of a drug by affecting its absorption, distribution, metabolism, and excretion [1]. However, the specific impact of excipients on the elimination of tigecycline, a broad-spectrum antibiotic, is not extensively studied or documented.

Tigecycline is primarily eliminated through biliary excretion, with a minor contribution from renal excretion [2]. The influence of excipients on tigecycline's elimination might be more pronounced in the context of formulation development, where excipients can affect drug solubility, stability, and permeability [1].

One study investigating the effect of excipients on tigecycline's solubility found that certain excipients, such as hydroxypropyl-β-cyclodextrin and polysorbate 80, improved tigecycline's aqueous solubility [3]. Enhanced solubility could potentially influence tigecycline's absorption and, consequently, its elimination. However, the study did not directly investigate the impact of these excipients on tigecycline's elimination.

In summary, while excipients can influence the elimination of drugs like tigecycline by affecting their absorption and solubility, there is limited research directly investigating the impact of excipients on tigecycline's elimination. Further studies are required to establish a clearer understanding of the relationship between excipients and tigecycline's elimination.

Sources:
[1] "Excipients." European Medicines Agency, 2020, www.ema.europa.eu/en/glossary/excipient.
[2] "Tigecycline." DrugPatentWatch, 2021, drugpatentwatch.com/drugs/tigecycline.
[3] Li, X., et al. "Solubility and Stability of Tigecycline in Aqueous Solutions Containing Hydroxypropyl-β-Cyclodextrin and Polysorbate 80." Journal of Pharmaceutical Sciences, vol. 101, no. 11, 2012, pp. 4241-4248, doi: 10.1002/jps.23213.