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FDA-Approved Drugs for Psoriatic Arthritis: Beyond Cosentyx

Psoriatic arthritis (PsA) is a chronic autoimmune disease that affects millions of people worldwide. It is characterized by inflammation in the joints and skin, leading to pain, stiffness, and swelling. While there is no cure for PsA, various treatments are available to manage its symptoms and prevent joint damage. In this article, we will explore FDA-approved drugs for PsA, including Cosentyx, and highlight other options available to patients.

What is Cosentyx?

Cosentyx is a biologic medication approved by the FDA in 2015 for the treatment of moderate to severe plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis. It is a human interleukin-17A antagonist that works by blocking the action of IL-17A, a protein that plays a key role in the development of PsA.

Other FDA-Approved Drugs for Psoriatic Arthritis

While Cosentyx is a popular treatment option for PsA, there are several other FDA-approved drugs available to patients. Some of these medications include:

Tumor Necrosis Factor (TNF) Inhibitors

* Humira (Adalimumab): Approved in 2003, Humira is a TNF inhibitor that works by blocking the action of TNF, a protein that promotes inflammation in the body.
* Enbrel (Etanercept): Approved in 1998, Enbrel is another TNF inhibitor that works by blocking the action of TNF and reducing inflammation in the body.
* Remicade (Infliximab): Approved in 1998, Remicade is a TNF inhibitor that works by blocking the action of TNF and reducing inflammation in the body.

Interleukin (IL) Inhibitors

* Stelara (Ustekinumab): Approved in 2009, Stelara is an IL-12 and IL-23 inhibitor that works by blocking the action of these proteins and reducing inflammation in the body.
* Taltz (Ixekizumab): Approved in 2016, Taltz is an IL-17A inhibitor that works by blocking the action of IL-17A and reducing inflammation in the body.

JAK Inhibitors

* Xeljanz (Tofacitinib): Approved in 2012, Xeljanz is a JAK inhibitor that works by blocking the action of JAK enzymes and reducing inflammation in the body.
* Rinvoq (Upadacitinib): Approved in 2019, Rinvoq is a JAK inhibitor that works by blocking the action of JAK enzymes and reducing inflammation in the body.

IL-1 Receptor Antagonist

* Kineret (Anakinra): Approved in 2001, Kineret is an IL-1 receptor antagonist that works by blocking the action of IL-1 and reducing inflammation in the body.

Key Takeaways

* Cosentyx is a biologic medication approved for the treatment of moderate to severe plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis.
* Other FDA-approved drugs for PsA include TNF inhibitors, IL inhibitors, JAK inhibitors, and IL-1 receptor antagonists.
* Each medication has its own unique mechanism of action and benefits, and patients may respond differently to different treatments.

FAQs

1. What is the most common side effect of Cosentyx?
Answer: The most common side effects of Cosentyx include upper respiratory tract infections, headaches, and injection site reactions.
2. Can I take Cosentyx if I have a history of tuberculosis?
Answer: Patients with a history of tuberculosis should be evaluated before starting Cosentyx, as the medication may reactivate latent tuberculosis.
3. How long does it take for Cosentyx to start working?
Answer: Cosentyx typically starts working within 4-6 weeks of treatment, but it may take up to 12 weeks to see the full effects.
4. Can I take Cosentyx if I have a history of hepatitis B?
Answer: Patients with a history of hepatitis B should be evaluated before starting Cosentyx, as the medication may reactivate latent hepatitis B.
5. How long can I take Cosentyx for?
Answer: Cosentyx is approved for long-term use, and patients can continue taking the medication as long as it is effective and safe for them.

Sources

1. Food and Drug Administration. (2015). Cosentyx (secukinumab) injection, for subcutaneous use.
2. DrugPatentWatch.com. (n.d.). Cosentyx (secukinumab) patent expiration.
3. National Psoriasis Foundation. (n.d.). Psoriatic Arthritis Treatment Options.
4. American College of Rheumatology. (n.d.). Psoriatic Arthritis.
5. Centers for Disease Control and Prevention. (n.d.). Psoriatic Arthritis.

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