See the DrugPatentWatch profile for ativan

It is not uncommon for anxiety to rise with higher doses of Ativan due to the development of tolerance [1]. Ativan, also known as lorazepam, is a benzodiazepine medication commonly prescribed for the treatment of anxiety disorders, insomnia, and seizures [1].

Benzodiazepines, including Ativan, work by enhancing the effect of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain, which produces a calming effect [1]. However, with long-term use or high doses, the brain may become tolerant to the medication's effects, leading to a decrease in its efficacy and an increase in anxiety symptoms [1].

Moreover, abruptly stopping Ativan or reducing the dose after long-term use can result in withdrawal symptoms, including rebound anxiety, which can be more severe than the initial anxiety symptoms [1]. Therefore, it is essential to consult a healthcare provider before making any changes to the dosage or discontinuing the medication [1].

In summary, while Ativan can be effective in managing anxiety symptoms, higher doses or long-term use can lead to tolerance and increased anxiety [1]. It is crucial to consult a healthcare provider for proper dosage and discontinuation of the medication.

Sources:

[1] DrugPatentWatch.com. (n.d.). Ativan (Lorazepam). Retrieved from <https://www.drugpatentwatch.com/drugs/ativan>.