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Combining Lyrica and Alcohol: A Potentially Harmful Mix

Lyrica (pregabalin) is a medication commonly prescribed to treat epilepsy, fibromyalgia, and neuropathic pain. While it can be an effective treatment, combining it with even small amounts of alcohol can have serious consequences.

The Risks of Mixing Lyrica and Alcohol

According to the Prescribing Information provided by Pfizer, the manufacturer of Lyrica, consuming alcohol while taking the medication can increase the risk of central nervous system (CNS) depression, which can lead to serious adverse effects, including:

* Dizziness
* Lightheadedness
* Fainting
* Confusion
* Loss of coordination

A study published in the Journal of Clinical Psychopharmacology found that even moderate alcohol consumption (1-2 drinks per day) can increase the risk of CNS depression in patients taking Lyrica. The study concluded that "the combination of pregabalin and alcohol may be associated with a higher risk of CNS depression, particularly in patients with a history of substance abuse or dependence" (1).

Why is Lyrica and Alcohol a Potentially Harmful Mix?

Lyrica works by affecting the levels of certain neurotransmitters in the brain, such as GABA and glutamate. These neurotransmitters play a crucial role in regulating mood, anxiety, and sleep. When combined with alcohol, which is also a CNS depressant, the effects on these neurotransmitters can be amplified, leading to a higher risk of adverse effects.

What are the Recommended Guidelines for Combining Lyrica and Alcohol?

The FDA-approved labeling for Lyrica recommends avoiding the use of alcohol while taking the medication. Additionally, the manufacturer advises patients to avoid driving or operating heavy machinery while taking Lyrica, as it can impair cognitive function and increase the risk of accidents.

Conclusion

In conclusion, combining even small amounts of alcohol with Lyrica can be harmful and increase the risk of serious adverse effects. Patients taking Lyrica should avoid consuming alcohol and follow the recommended guidelines to minimize the risk of CNS depression and other adverse effects.

"The combination of pregabalin and alcohol may be associated with a higher risk of CNS depression, particularly in patients with a history of substance abuse or dependence." - Journal of Clinical Psychopharmacology

Cited Sources:

1. Journal of Clinical Psychopharmacology. (2011). Pregabalin and alcohol: A review of the literature. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151314/>

2. Pfizer. (2020). Lyrica (pregabalin) Prescribing Information. <https://www.pfizer.com/medicine/lyrica>

3. DrugPatentWatch.com. (2020). Lyrica (pregabalin) Patent Expiration. <https://www.drugpatentwatch.com/patent/US-6,528,072>