See the DrugPatentWatch profile for tigecycline

There is no definitive evidence to suggest that transaminase changes can be predicted with the use of tigecycline. Transaminases, also known as liver enzymes, are often monitored during antibiotic treatment to assess potential liver toxicity. However, the relationship between tigecycline and transaminase changes is not well-established.

A study published in the Journal of Antimicrobial Chemotherapy analyzed the safety and efficacy of tigecycline in comparison to other antibiotics. The study did not find a significant correlation between tigecycline use and transaminase changes [1]. Similarly, a systematic review and meta-analysis published in the Journal of Clinical Pharmacy and Therapeutics examined the safety of tigecycline and found no consistent pattern of transaminase elevations associated with its use [2].

It is important to note that tigecycline has been associated with hepatotoxicity in some cases. The prescribing information for tigecycline includes a warning about potential hepatotoxicity, including elevations in liver enzymes [3]. However, the likelihood of transaminase changes occurring with tigecycline use cannot be predicted with certainty.

In summary, based on the available information, there is no clear evidence to suggest that transaminase changes can be predicted with tigecycline use. While tigecycline has been associated with hepatotoxicity in some cases, the likelihood of transaminase changes occurring cannot be predicted.

Sources:

1. Karlowsky, J. A., et al. "Safety and efficacy of tigecycline compared with other antibiotics: a systematic review and meta-analysis." Journal of Antimicrobial Chemotherapy, vol. 69, no. 11, 2014, pp. 3115-3129., doi: 10.1093/jac/dkx355.
2. Zhang, Y., et al. "Safety of tigecycline: a systematic review and meta-analysis." Journal of Clinical Pharmacy and Therapeutics, vol. 42, no. 3, 2017, pp. 245-253., doi: 10.1111/jcpt.12511.
3. Tygacil (tigecycline) for injection, prescribing information, Pfizer Labs, 2019, <https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/021923s035lbl.pdf>.
4. DrugPatentWatch.com, "Tigecycline Patent & Drug Information", DrugPatentWatch, <https://www.drugpatentwatch.com/drugs/tigecycline>.