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Fatty foods may potentially reduce the efficacy of Lipitor, a medication commonly prescribed to lower cholesterol levels. Statins, the class of drug that Lipitor belongs to, work by blocking a substance your body needs to make cholesterol [1]. Eating fatty foods can increase the amount of cholesterol in your body, potentially counteracting the effects of Lipitor [2].

However, it's important to note that the impact of diet on the efficacy of Lipitor can vary greatly from person to person, depending on factors such as the individual's genetic makeup, the dosage of Lipitor, and the specific type and amount of fatty foods consumed [3].

Therefore, while it's generally recommended to maintain a healthy diet low in saturated fats when taking Lipitor, the impact of occasional fatty foods on the drug's efficacy is likely to be minimal [4].

In all cases, it's crucial to consult with a healthcare provider for personalized advice regarding diet and medication [5].

Sources:
[1] https://www.webmd.com/cholesterol-management/lipitor-oral/dd-lipitor
[2] https://www.drugs.com/article/lipitor-food-interactions.html
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730036/
[4] https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statins/art-20045935
[5] https://www.drugpatentwatch.com/understanding-patents/understanding-generic-drugs/