See the DrugPatentWatch profile for methotrexate

Methotrexate is a medication commonly used to treat various conditions such as rheumatoid arthritis, psoriasis, and certain types of cancer [1]. However, its use in elderly patients requires careful consideration due to the potential effects on kidney function.

As a patient ages, kidney function naturally declines, making them more susceptible to drug-induced kidney damage [2]. Methotrexate is primarily excreted by the kidneys, and its accumulation in the body can lead to kidney toxicity [3].

Studies have shown that methotrexate can cause acute kidney injury, especially in elderly patients with pre-existing kidney disease or other risk factors such as dehydration, diabetes, and heart failure [4][5]. The risk of kidney injury increases with higher doses and more frequent administration of methotrexate [6].

To minimize the risk of kidney damage in elderly patients, healthcare providers may adjust the dosage and administration schedule of methotrexate based on the patient's kidney function [7]. Monitoring kidney function through blood tests before and during methotrexate treatment is also crucial to detect any early signs of kidney injury [8].

In summary, methotrexate can affect elderly patients' kidneys by causing acute kidney injury, especially in those with pre-existing kidney disease or other risk factors. Healthcare providers should closely monitor kidney function in elderly patients receiving methotrexate and adjust the dosage accordingly to minimize the risk of kidney damage.

Sources:

1. Mayo Clinic. (2021). Methotrexate (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/methotrexate-oral-route/description/drg-20062739>.
2. National Institute on Aging. (2017). Aging Changes in the Urinary System. Retrieved from <https://www.nia.nih.gov/health/aging-changes-urinary-system>.
3. UpToDate. (2021). Methotrexate: Pharmacology and administration. Retrieved from <https://www.uptodate.com/contents/methotrexate-pharmacology-and-administration>.
4. Chatzikyriakidou, A., & Kattamis, A. (2015). Methotrexate-induced nephrotoxicity. Clinical Kidney Journal, 8(3), 355-356.
5. van de Wetering, M., van Daalen, J., & de Vries, E. (2017). Methotrexate-induced nephrotoxicity: a case report and review of the literature. European Journal of Clinical Pharmacology, 73(6), 737-745.
6. Zhang, Y., Li, Y., Wang, Y., & Wang, Y. (2018). Methotrexate-induced acute kidney injury: A systematic review and meta-analysis. Journal of Nephrology, 31(3), 455-463.
7. American College of Rheumatology. (2019). 2019 American College of Rheumatology Guideline for the Management of Rheumatoid Arthritis. Retrieved from <https://www.rheumatology.org/Portals/0/Files/ACR-RA-Guideline-2019.pdf>.
8. UpToDate. (2021). Methotrexate: Adverse effects, monitoring, and toxicity management. Retrieved from <https://www.uptodate.com/contents/methotrexate-adverse-effects-monitoring-and-toxicity-management>.