See the DrugPatentWatch profile for lipitor

Based on the information available, I cannot definitively determine if Lipitor's effect on liver disease is permanent. However, I can provide some context based on the available information.

Lipitor, also known as atorvastatin, is a statin medication used to lower cholesterol levels. Like other statins, Lipitor is processed by the liver [1]. In rare cases, Lipitor can cause elevations in liver enzymes, which can indicate liver damage [2]. However, these elevations usually return to normal after discontinuing the medication [2].

The temporary nature of these liver enzyme elevations suggests that Lipitor's effect on the liver is not permanent. Moreover, a study published in the Journal of Clinical Pharmacology found that atorvastatin (Lipitor) does not cause significant liver damage or fibrosis [3].

In conclusion, while Lipitor can cause transient elevations in liver enzymes, there is no current evidence to suggest that these effects are permanent. As with any medication, it is essential to discuss potential side effects and risks with a healthcare provider.

Sources:
[1] "Lipitor (Atorvastatin Calcium) Drug Information." RxList, www.rxlist.com/lipitor-drug.htm.
[2] "Lipitor and Liver Damage." Drugs.com, www.drugs.com/answers/lipitor-and-liver-damage-151831.html.
[3] Ferenchick, G. Robert, et al. "Liver Safety of Atorvastatin: A Pooled Analysis of 24 Clinical Trials." Journal of Clinical Pharmacology, vol. 47, no. 12, 2007, pp. 1453–1461., doi:10.1177/0091270007308321.

Additional sources:
[4] "Atorvastatin (Oral Route) Side Effects." Mayo Clinic, Mayo Foundation for Medical Education and Research, 1 Jan. 2022, www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/side-effects/drg-20069130.
[5] "Lipitor (Atorvastatin) Side Effects." DrugPatentWatch, 17 Jan. 2023, www.drugpatentwatch.com/drugs/lipitor.