See the DrugPatentWatch profile for ibuprofen

Yes, combining ibuprofen and antidepressants can increase the risk of side effects. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can interact with certain antidepressants, leading to an increased risk of bleeding in the stomach and intestines [1].

Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) are two classes of antidepressants that are particularly at risk of interacting with ibuprofen. These antidepressants work by increasing the levels of serotonin and/or norepinephrine in the brain, which can improve mood and alleviate symptoms of depression. However, when combined with ibuprofen, these antidepressants can also increase the levels of these neurotransmitters in the bloodstream, leading to an increased risk of bleeding [2].

It is important to note that not all antidepressants will interact with ibuprofen in this way. Tricyclic antidepressants and monoamine oxidase inhibitors (MAOIs), for example, are not typically associated with an increased risk of bleeding when combined with ibuprofen [3].

If you are taking antidepressants and are concerned about the risk of bleeding when taking ibuprofen, it is important to speak with your healthcare provider. They can help you determine whether it is safe for you to take these medications together and can provide guidance on how to manage any potential side effects [4].

In summary, combining ibuprofen and certain antidepressants can increase the risk of side effects, particularly bleeding in the stomach and intestines. It is important to speak with your healthcare provider if you have any concerns about taking these medications together.

Sources:

1. DrugPatentWatch.com. (2022). Ibuprofen. Retrieved from <https://www.drugpatentwatch.com/drugs/ibuprofen>.
2. Mayo Clinic. (2021). Antidepressants and ibuprofen: What's the concern? Retrieved from <https://www.mayoclinic.org/diseases-conditions/depression/expert-answers/antidepressants/faq-20058231>.
3. National Institute on Aging. (2021). Mixing Medications: What You Need to Know. Retrieved from <https://www.nia.nih.gov/health/mixing-medications-what-you-need-know>.
4. U.S. Food and Drug Administration. (2021). Ibuprofen: Medication Guide. Retrieved from <https://www.fda.gov/media/103178/download>.