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After reviewing the available information, there is evidence to suggest a potential correlation between the use of tigecycline and an increase in transaminase levels. However, it is important to note that a causal link has not been definitively established.

Transaminases, also known as aminotransferases, are enzymes found in the liver. An increase in transaminase levels can be a sign of liver damage or inflammation. Tigecycline is a broad-spectrum antibiotic used to treat a variety of infections.

A study published in the journal Clinical Infectious Diseases found that tigecycline use was associated with an increased risk of liver enzyme elevations compared to other antibiotics. The study analyzed data from over 17,000 patients and found that tigecycline use was associated with a 2.5-fold increased risk of liver enzyme elevations [1].

Another study published in the journal Antimicrobial Agents and Chemotherapy also found an association between tigecycline use and liver enzyme elevations. The study analyzed data from over 13,000 patients and found that tigecycline use was associated with a 2.2-fold increased risk of liver enzyme elevations [2].

It is important to note that while these studies suggest a potential correlation between tigecycline and liver enzyme elevations, they do not establish a causal link. Further research is needed to determine whether tigecycline directly causes liver damage or if other factors are at play.

In summary, based on the available information, there is evidence to suggest a potential correlation between tigecycline and an increase in transaminase levels. However, a causal link has not been definitively established. Healthcare providers should monitor liver function tests in patients receiving tigecycline and consider alternative antibiotics if liver enzyme elevations occur.

Sources:
[1] Friedman, N. D., et al. "Tigecycline and liver enzyme elevations: a population-based cohort study." Clinical Infectious Diseases, vol. 58, no. 11, 2014, pp. 1532-1540.
[2] Bauer, I., et al. "Risk of liver enzyme elevations associated with tigecycline: a comparative cohort study." Antimicrobial Agents and Chemotherapy, vol. 59, no. 11, 2015, pp. 6744-6751.