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Aspirin is known to have blood-thinning properties, which can help reduce the risk of blood clots in smokers. However, other factors can impact aspirin's effect on a smoker's clotting.

Firstly, the dosage of aspirin is crucial. Lower doses of aspirin (75-100mg) are typically used for long-term prevention of heart attacks and strokes, while higher doses (300-1200mg) are used for short-term treatment of symptoms [1]. It's important to note that higher doses of aspirin may increase the risk of bleeding [1].

Secondly, the timing of aspirin intake in relation to smoking can affect its efficacy. A study found that smoking within an hour of taking aspirin can reduce the drug's ability to prevent blood clots [2].

Thirdly, other medications and health conditions can interact with aspirin and affect its ability to prevent blood clots. For instance, nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, can decrease aspirin's effectiveness [3]. Similarly, conditions like von Willebrand disease, hemophilia, and severe liver disease can also impact aspirin's effect on clotting [4].

Lastly, genetic factors can play a role in aspirin's effect on clotting. Certain genetic variations can affect the way aspirin is metabolized, which can impact its ability to prevent blood clots [5].

In conclusion, while aspirin can help reduce the risk of blood clots in smokers, its effectiveness can be influenced by various factors, including dosage, timing, other medications, health conditions, and genetic factors.

Sources:
[1] "Aspirin: MedlinePlus Drug Information." U.S. National Library of Medicine, <https://medlineplus.gov/druginfo/meds/a601104.html>.
[2] "Smoking Cigarettes After Taking Aspirin Can Reduce Its Benefits." ScienceDaily, <https://www.sciencedaily.com/releases/2007/03/070327141513.htm>.
[3] "Can I Combine Aspirin and Ibuprofen?" Mayo Clinic, Mayo Foundation for Medical Education and Research, 11 Jan. 2021, <https://www.mayoclinic.org/diseases-conditions/heart-disease/expert-answers/ibuprofen-and-aspirin/faq-20058088>.
[4] "Aspirin: Uses, Side Effects, Interactions, Dosage, and Warning." Drugs.com, <https://www.drugs.com/aspirin.html>.
[5] "Aspirin Resistance." Genetics Home Reference, U.S. National Library of Medicine, <https://medlineplus.gov/genetics/condition/aspirin-resistance/>.