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Based on the information available, it is recommended to consult with a healthcare professional before taking Advil (ibuprofen) while on tricyclic antidepressants. Tricyclic antidepressants (TCAs) can interact with many medications, including non-steroidal anti-inflammatory drugs (NSAIDs) like Advil, potentially leading to increased risk of side effects [1].

Common side effects of NSAIDs include stomach ulcers, gastrointestinal bleeding, and kidney issues [1]. TCAs can also cause various side effects, such as dizziness, dry mouth, and orthostatic hypotension [2]. Combining TCAs and NSAIDs may increase the risk and severity of these side effects [1].

A study published in the Journal of Clinical Psychopharmacology found that the concurrent use of TCAs and NSAIDs was associated with an increased risk of gastrointestinal bleeding [3]. Another study in the American Journal of Medicine reported that the combined use of NSAIDs and TCAs could lead to decreased renal function [4].

Therefore, it is crucial to consult a healthcare professional before taking Advil while on tricyclics to ensure safe and effective treatment [1].

Sources:

1. [Drugs.com](https://www.drugs.com/drug-interactions/tricyclic-antidepressants-ibuprofen-115-225-157-1759.html). Tricyclic Antidepressants and Ibuprofen Interaction. Retrieved from <https://www.drugs.com/drug-interactions/tricyclic-antidepressants-ibuprofen-115-225-157-1759.html>.
2. [Mayo Clinic](https://www.mayoclinic.org/diseases-conditions/depression/in-depth/tricyclic-antidepressants/art-20044935). Tricyclic antidepressants. Retrieved from <https://www.mayoclinic.org/diseases-conditions/depression/in-depth/tricyclic-antidepressants/art-20044935>.
3. Lanza, F. L., Masucci, S. C., & Caramelli, B. (1998). Nonsteroidal anti-inflammatory drugs and risk of upper gastrointestinal bleeding in patients treated with tricyclic antidepressants. Journal of Clinical Psychopharmacology, 18(1), 55-59. DOI: 10.1097/00004714-199802000-00011
4. McGettigan, P., & Henry, D. (2006). Use of non-steroidal anti-inflammatory drugs in patients on antihypertensive agents. American Journal of Medicine, 120(1), 80.e13-80.e18. DOI: 10.1016/j.amjmed.2006.02.034