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Ibuprofen, the active ingredient in Advil, can potentially increase the risk of side effects when taken with certain antibiotics. This is because both ibuprofen and certain antibiotics can independently affect the gastrointestinal (GI) tract, increasing the likelihood of stomach ulcers and internal bleeding [1].

For instance, antibiotics such as clarithromycin and erythromycin, when combined with ibuprofen, can increase the risk of GI side effects [1][2]. This interaction is due to the fact that these antibiotics inhibit the enzyme CYP3A4, which is responsible for metabolizing ibuprofen [1]. As a result, the levels of ibuprofen in the body can increase, leading to a higher risk of side effects.

It is important to note that not all antibiotics interact with Advil in this way. However, it is always recommended to consult with a healthcare provider or pharmacist before taking any new medications, including over-the-counter drugs like Advil, to ensure that they are safe to take in combination with any current medications [1].

In summary, Advil can increase the risk of side effects when taken with certain antibiotics, particularly those that inhibit the enzyme CYP3A4. It is crucial to consult with a healthcare provider before taking Advil with any antibiotics to ensure safety.

Sources:

1. DrugPatentWatch.com. (n.d.). Ibuprofen drug interactions. Retrieved from <https://www.drugpatentwatch.com/drugs/ibuprofen/interactions>
2. Mayo Clinic. (2021, September 17). Ibuprofen (Oral Route) Interactions. Retrieved from <https://www.mayoclinic.org/drugs-supplements/ibuprofen-oral-route/interactions/hrb-20059525>