See the DrugPatentWatch profile for acyclovir

Acyclovir is a commonly prescribed antiviral medication used to treat herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections [1]. However, it can cause kidney damage, particularly in patients with pre-existing kidney disease or dehydration [2]. Here are some precautions that should be taken to prevent acyclovir-induced kidney damage:

1. Proper Dosage: It is essential to take the prescribed dosage of acyclovir and not exceed the recommended dose [2]. Higher doses increase the risk of kidney damage [2].
2. Hydration: Drinking plenty of fluids can help prevent kidney damage by maintaining proper hydration [2]. Dehydration can increase the concentration of acyclovir in the body, leading to kidney damage [2].
3. Monitoring Kidney Function: Patients taking acyclovir should have their kidney function monitored regularly, especially if they have pre-existing kidney disease [2]. This can help detect any early signs of kidney damage and allow for prompt treatment [2].
4. Duration of Therapy: The duration of acyclovir therapy should be as short as possible to minimize the risk of kidney damage [2].
5. Intravenous Administration: Intravenous administration of acyclovir should be given slowly over at least one hour to reduce the risk of kidney damage [2].
6. Alternative Medications: If a patient has pre-existing kidney disease or experiences kidney damage while taking acyclovir, alternative antiviral medications may be considered [2].

It is important to note that while acyclovir can cause kidney damage, it is a valuable medication for treating HSV and VZV infections [1]. Patients should discuss any concerns about acyclovir and kidney damage with their healthcare provider [2].

Sources:
[1] "Acyclovir" (Drugs.com) <https://www.drugs.com/acyclovir.html>.
[2] "Acyclovir and Kidney Damage" (DrugPatentWatch.com) <https://drugpatentwatch.com/drug/acyclovir-and-kidney-damage>.