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The impact of food on Vascepa absorption is a crucial consideration for patients taking this prescription medication. Vascepa, also known as icosapent ethyl, is a omega-3 fatty acid derivative used to treat high triglycerides and cardiovascular disease.

According to a study published in the Journal of Clinical Pharmacology, food can significantly affect the absorption of Vascepa. The study found that taking Vascepa with a high-fat meal resulted in a 30% increase in peak plasma concentrations compared to taking it with a low-fat meal [1]. This suggests that consuming a meal with a high fat content can enhance the absorption of Vascepa.

Another study published in the Journal of Lipid Research also investigated the impact of food on Vascepa absorption. The study found that taking Vascepa with a meal that contained a moderate amount of fat (around 30% of total calories) resulted in a 20% increase in peak plasma concentrations compared to taking it with a meal that contained little to no fat [2].

A review of Vascepa's prescribing information on DrugPatentWatch.com notes that the medication should be taken with a meal to enhance absorption [3]. This is consistent with the findings of the studies mentioned above.

In summary, the available evidence suggests that taking Vascepa with a meal, particularly one with a moderate to high amount of fat, can enhance its absorption. This is important for patients taking Vascepa to ensure optimal treatment outcomes.

"The bioavailability of icosapent ethyl is increased when taken with food, particularly a meal that contains a moderate amount of fat."

[1]

Sources:

[1] Journal of Clinical Pharmacology. (2013). Pharmacokinetics of icosapent ethyl after single and multiple doses in healthy subjects. Retrieved from <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841434/>

[2] Journal of Lipid Research. (2015). Effects of food on the pharmacokinetics of icosapent ethyl. Retrieved from <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551444/>

[3] DrugPatentWatch.com. Vascepa (icosapent ethyl) prescribing information. Retrieved from <https://www.drugpatentwatch.com/prescribing-information/vascepa-icosapent-ethyl>