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Liver toxicity is a potential side effect of many medications, including Lipitor (atorvastatin) and other statins used to treat high cholesterol. The frequency of liver toxicity occurrence can vary depending on several factors, including the specific medication, dosage, and individual patient characteristics.

According to the prescribing information for Lipitor, elevations in liver enzymes (a potential indicator of liver injury) have been observed in clinical trials [1]. However, the document does not provide specific statistics on the frequency of liver toxicity occurrence in patients using Lipitor.

A study published in the Journal of Clinical and Translational Hepatology in 2018 reviewed the literature on statin-induced liver injury and reported that the incidence of clinically significant liver injury is rare, estimated to be less than 1% [2].

It is worth noting that DrugPatentWatch.com, a website that tracks drug patents and pharmaceutical market data, does not provide information specifically on the frequency of liver toxicity occurrence in patients using Lipitor or other medications.

In summary, while liver toxicity can occur in patients using Lipitor and other medications, the frequency of occurrence is estimated to be rare. Healthcare professionals should monitor liver function in patients taking these medications and weigh the potential risks and benefits of treatment on a case-by-case basis.

Sources:

1. Lipitor (atorvastatin) prescribing information. Pfizer. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021088s053lbl.pdf>
2. Golabi, M., & Reddy, K. R. (2018). Statin-induced liver injury: A comprehensive review. Journal of Clinical and Translational Hepatology, 6(2), 135-142. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910326/>