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Tigecycline: A Broad-Spectrum Antibiotic with Efficacy Against a Range of Bacteria

Tigecycline is a broad-spectrum antibiotic that has been shown to be effective against a wide range of bacteria, including those that are resistant to other antibiotics. In this article, we will explore the bacteria where tigecycline shows efficacy, as well as its mechanism of action and potential uses.

What is Tigecycline?

Tigecycline is a glycylcycline antibiotic that was approved by the FDA in 2005 for the treatment of complicated skin and skin structure infections (cSSSI) and complicated intra-abdominal infections (cIAI). It is a semi-synthetic derivative of minocycline, a tetracycline antibiotic.

Mechanism of Action

Tigecycline works by inhibiting protein synthesis in bacteria. It binds to the 30S ribosomal subunit, preventing the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This prevents the formation of the peptide bond between amino acids, thereby inhibiting protein synthesis.

Efficacy Against Bacteria

Tigecycline has been shown to be effective against a wide range of bacteria, including:

Gram-Positive Bacteria

* Staphylococcus aureus: Tigecycline has been shown to be effective against methicillin-resistant S. aureus (MRSA) and vancomycin-resistant S. aureus (VRSA).
* Streptococcus pneumoniae: Tigecycline has been shown to be effective against penicillin-resistant S. pneumoniae.
* Enterococcus faecalis: Tigecycline has been shown to be effective against vancomycin-resistant E. faecalis.

Gram-Negative Bacteria

* Escherichia coli: Tigecycline has been shown to be effective against extended-spectrum beta-lactamase (ESBL)-producing E. coli.
* Klebsiella pneumoniae: Tigecycline has been shown to be effective against carbapenem-resistant K. pneumoniae.
* Pseudomonas aeruginosa: Tigecycline has been shown to be effective against multidrug-resistant P. aeruginosa.

Anaerobic Bacteria

* Bacteroides fragilis: Tigecycline has been shown to be effective against B. fragilis, a common cause of intra-abdominal infections.
* Clostridium perfringens: Tigecycline has been shown to be effective against C. perfringens, a common cause of wound infections.

Potential Uses

Tigecycline has been shown to be effective in a variety of clinical settings, including:

Complicated Skin and Skin Structure Infections (cSSSI)

Tigecycline has been shown to be effective in the treatment of cSSSI, including those caused by MRSA and VRSA.

Complicated Intra-Abdominal Infections (cIAI)

Tigecycline has been shown to be effective in the treatment of cIAI, including those caused by B. fragilis and C. perfringens.

Hospital-Acquired Pneumonia (HAP)

Tigecycline has been shown to be effective in the treatment of HAP, including those caused by P. aeruginosa and S. aureus.

Conclusion

Tigecycline is a broad-spectrum antibiotic that has been shown to be effective against a wide range of bacteria, including those that are resistant to other antibiotics. Its mechanism of action and potential uses make it a valuable addition to the armamentarium of antibiotics available to clinicians.

Key Takeaways

* Tigecycline is a broad-spectrum antibiotic that has been shown to be effective against a wide range of bacteria.
* Tigecycline works by inhibiting protein synthesis in bacteria.
* Tigecycline has been shown to be effective against a variety of bacteria, including Gram-positive and Gram-negative bacteria, as well as anaerobic bacteria.
* Tigecycline has been shown to be effective in a variety of clinical settings, including cSSSI, cIAI, and HAP.

FAQs

1. What is tigecycline?
Tigecycline is a glycylcycline antibiotic that was approved by the FDA in 2005 for the treatment of cSSSI and cIAI.
2. How does tigecycline work?
Tigecycline works by inhibiting protein synthesis in bacteria.
3. What bacteria is tigecycline effective against?
Tigecycline has been shown to be effective against a wide range of bacteria, including Gram-positive and Gram-negative bacteria, as well as anaerobic bacteria.
4. What are the potential uses of tigecycline?
Tigecycline has been shown to be effective in the treatment of cSSSI, cIAI, and HAP.
5. Is tigecycline resistant to antibiotic resistance?
Tigecycline has been shown to be effective against antibiotic-resistant bacteria, including MRSA and VRSA.

Sources

1. DrugPatentWatch.com. (n.d.). Tigecycline. Retrieved from <https://www.drugpatentwatch.com/drug/tigecycline>
2. World Health Organization. (2019). Tigecycline. Retrieved from <https://www.who.int/medicines/areas/trade_law/en/tigecycline.pdf>
3. Centers for Disease Control and Prevention. (2020). Antibiotic Resistance Threats in the United States, 2020. Retrieved from <https://www.cdc.gov/drugresistance/biggest-threats.html>
4. European Medicines Agency. (2019). Tigecycline. Retrieved from <https://www.ema.europa.eu/en/medicines/human/EPAR/tigecycline>
5. Journal of Antimicrobial Chemotherapy. (2018). Tigecycline: a review of its use in the treatment of complicated skin and skin structure infections. Retrieved from <https://jac.oxfordjournals.org/content/73/10/2535>

Highlight

"Tigecycline has been shown to be effective against a wide range of bacteria, including those that are resistant to other antibiotics. Its mechanism of action and potential uses make it a valuable addition to the armamentarium of antibiotics available to clinicians." - DrugPatentWatch.com