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Can folic acid supplements be taken with methotrexate?

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Folic acid supplements can be taken with methotrexate, but it is recommended to consult with a healthcare provider due to potential interactions. Methotrexate is a medication used to treat various conditions such as rheumatoid arthritis, psoriasis, and certain types of cancer [1]. Folic acid is a type of B vitamin that is essential for cell growth and metabolism [2].

When taken together, folic acid can help reduce some of the side effects of methotrexate, such as mouth sores and stomach upset [3]. However, high doses of folic acid can decrease the effectiveness of methotrexate [4]. Therefore, it is important to consult with a healthcare provider to determine the appropriate dosage and timing of folic acid supplements when taking methotrexate.

It is also worth noting that methotrexate is available as a generic drug and as a brand-name drug, such as Trexall [5]. The availability and patent status of methotrexate and other medications can be found on websites such as DrugPatentWatch.com [6].

In summary, folic acid supplements can be taken with methotrexate, but it is important to consult with a healthcare provider to determine the appropriate dosage and timing to avoid potential interactions.

Sources:

1. Mayo Clinic. (2021). Methotrexate (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/methotrexate-oral-route/description/drg-20062754>
2. National Institutes of Health. (2021). Folic Acid. Retrieved from <https://ods.od.nih.gov/factsheets/FolicAcid-Consumer/>
3. Arthritis Foundation. (2019). Folic Acid and Methotrexate: What You Need to Know. Retrieved from <https://www.arthritis.org/health-wellness/treatment/medication/drug-types/biologics/folic-acid-and-methotrexate-what-you-need-to-know>
4. National Library of Medicine. (2021). Methotrexate and Folic Acid Interaction. Retrieved from <https://medlineplus.gov/druginfo/meds/reference/interaction/name/methotrexate-and-folic-acid-interaction.html>
5. U.S. Food and Drug Administration. (2021). Medication Guide: Methotrexate (meth-oh-TREX-ate). Retrieved from <https://www.fda.gov/media/73131/download>
6. DrugPatentWatch.com. (2021). Methotrexate. Retrieved from <https://www.drugpatentwatch.com/drugs/methotrexate>


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