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Ibuprofen, the active ingredient in Advil, belongs to a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs) [1]. When using Advil over time, it is essential to understand its potential effects on the body.

Long-term use of Advil can lead to various side effects, which may include:

1. Gastrointestinal issues: NSAIDs like Advil can cause stomach ulcers, stomach bleeding, and other gastrointestinal problems [1]. These risks increase with the duration of use and higher dosages [1].

2. Cardiovascular risks: Long-term use of NSAIDs, including Advil, has been associated with an increased risk of heart attacks, strokes, and high blood pressure [1][2].

3. Kidney problems: Prolonged use of NSAIDs can lead to kidney damage, kidney disease, or even kidney failure [1].

4. Liver issues: Long-term use of NSAIDs may cause liver damage or hepatitis [1].

5. Central nervous system effects: NSAIDs can cause headaches, dizziness, and, in rare cases, ringing in the ears or loss of hearing [1].

It is crucial to consult a healthcare professional before starting or continuing Advil use, especially for extended periods. They can help determine the appropriate dosage and duration of treatment, as well as monitor for potential side effects [1].

Sources:
[1] "Ibuprofen (Oral Route) Side Effects." Mayo Clinic, Mayo Foundation for Medical Education and Research, 1 Sept. 2021, [www.mayoclinic.org/drugs-supplements/ibuprofen-oral-route/side-effects/drg-20069035](http://www.mayoclinic.org/drugs-supplements/ibuprofen-oral-route/side-effects/drg-20069035).
[2] "Ibuprofen: MedlinePlus Drug Information." MedlinePlus, U.S. National Library of Medicine, 15 Sept. 2021, medlineplus.gov/druginfo/meds/a682035.html.
[3] "Ibuprofen (Advil, Motrin) Drug Patent Expiration Dates." DrugPatentWatch, drugpatentwatch.com/ibuprofen-advil-motrin-patent-expiration-dates/.