See the DrugPatentWatch profile for sapropterin

Biomarkers play a significant role in adjusting sapropterin dosage. Sapropterin is a drug used to reduce the symptoms of phenylketonuria (PKU), a genetic disorder characterized by a deficiency of the enzyme needed to break down phenylalanine, an amino acid found in protein-rich foods [1].

Biomarkers are measurable indicators of the severity or presence of a disease or condition, and in the case of PKU, biomarkers such as blood phenylalanine levels are used to monitor the effectiveness of sapropterin therapy and guide dosage adjustments [2]. By regularly measuring biomarker levels, healthcare providers can assess the patient's response to the current dosage of sapropterin and make informed decisions about increasing, decreasing, or maintaining the dosage [3].

According to DrugPatentWatch.com, sapropterin is currently available as a brand-name drug under the trade name Kuvan, and its patent is set to expire in 2024 [4]. This information highlights the importance of optimizing sapropterin dosage through the use of biomarkers, as it can improve treatment outcomes and reduce healthcare costs associated with PKU management [5].

In summary, biomarkers play a crucial role in adjusting sapropterin dosage by providing a quantifiable measure of the drug's effectiveness and enabling healthcare providers to make data-driven decisions about dosage adjustments.

Sources:
[1] National Institutes of Health. (2021). Phenylketonuria. Genetics Home Reference. <https://medlineplus.gov/genetics/condition/phenylketonuria/>
[2] National Institutes of Health. (2021). Biomarkers in disease. Genetics Home Reference. <https://medlineplus.gov/genetics/understanding/testing/biomarkers/>
[3] National Institutes of Health. (2021). Phenylalanine and tyrosine. Genetics Home Reference. <https://medlineplus.gov/genetics/testing/phenylalanineandtyrosine/>
[4] DrugPatentWatch.com. (2021). Sapropterin Dihydrochloride. <https://www.drugpatentwatch.com/drugs/sapropterin-dihydrochloride>
[5] National Institutes of Health. (2021). Phenylketonuria: Diagnosis and treatment. Genetics Home Reference. <https://medlineplus.gov/genetics/condition/phenylketonuria/#diagnosis-and-testing>