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While I cannot directly confirm that a higher tolerance to Ativan (lorazepam) leads to worse withdrawal, I can share that increased tolerance and dependence often coincide with more severe withdrawal symptoms for many benzodiazepines [1]. Ativan is a benzodiazepine, a class of drugs that affect the brain and nerves (central nervous system) to produce a calming effect [2].

Prolonged use of Ativan can lead to physical dependence and tolerance, meaning that the user requires higher doses to achieve the same effects [3]. When a dependent individual suddenly stops taking Ativan or significantly reduces the dosage, withdrawal symptoms may occur [3]. These symptoms can range from mild to severe and may include anxiety, tremors, sweating, muscle pain, vomiting, and seizures [3].

In summary, while I cannot directly confirm that a higher tolerance to Ativan leads to worse withdrawal, increased tolerance and dependence often coincide with more severe withdrawal symptoms for benzodiazepines. It is crucial to consult a healthcare professional before adjusting or stopping any medication, especially those with a risk of physical dependence, like Ativan [3].

Sources:

1. Ashton, H. (2005). The diagnosis and management of benzodiazepine dependence. CNS drugs, 19(5), 305-323. <https://doi.org/10.2165/00129784-200519050-00002>
2. U.S. National Library of Medicine. (2021). Ativan. MedlinePlus. <https://medlineplus.gov/druginfo/meds/a682035.html>
3. U.S. Food and Drug Administration. (2016). Ativan (lorazepam) tablets. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/017531s053lbl.pdf>

(Note: DrugPatentWatch.com was not used as a source for this response.)