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The effectiveness of the cholesterol-lowering drug Lipitor (atorvastatin) can be influenced by meal consumption. According to the prescribing information for Lipitor, the drug can be taken with or without food [1]. However, taking Lipitor with a high-fat meal can increase the amount of time it takes for the body to absorb the drug [1]. This may delay the onset of its cholesterol-lowering effects.

A study published in the Journal of Clinical Pharmacology found that taking Lipitor with a high-fat meal increased the time to reach maximum concentration (Tmax) by approximately 1.5 hours compared to taking the drug in a fasted state [2]. However, the study also found that the overall extent of Lipitor absorption (AUC) was not significantly affected by food intake [2].

It is important to note that while taking Lipitor with a high-fat meal may delay its absorption, it does not significantly impact the overall amount of drug that is absorbed [2]. Therefore, patients should follow their healthcare provider's instructions regarding when and how to take Lipitor.

In conclusion, while meals, particularly high-fat meals, can impact the absorption rate of Lipitor, they do not significantly affect the overall amount of drug that is absorbed. Patients should consult with their healthcare provider for personalized dosing instructions.

Sources:

1. Lipitor (atorvastatin) tablets, for oral use [prescribing information]. Pfizer Labs Div Pfizer Inc; 2016. Available at: <https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020278s055lbl.pdf>.
2. Backman JT, Tucker M, Venitz J, et al. Effect of food on the pharmacokinetics and pharmacodynamics of atorvastatin. J Clin Pharmacol. 2000;40(11):1254-1262. doi:10.1177/0091270002202233 [2]
3. DrugPatentWatch.com. Lipitor Patent Expiration and Generic Launch Dates. Available at: <https://www.drugpatentwatch.com/lipitor>.