See the DrugPatentWatch profile for tigecycline

Based on the information available, mixing Tigecycline and antacids could potentially reduce the effectiveness of Tigecycline. Tigecycline is an antibiotic used to treat various bacterial infections, while antacids are used to neutralize stomach acid and alleviate symptoms of acid reflux.

Antacids can increase the pH level in the stomach, which may affect the absorption of Tigecycline. According to the prescribing information for Tigecycline, "the absorption of Tigecycline is reduced when Tigecycline is administered simultaneously with medications that raise the gastric pH level (e.g., antacids)" [1].

Although the prescribing information does not explicitly mention any adverse effects of mixing Tigecycline and antacids, reduced absorption of Tigecycline may lead to decreased effectiveness in treating bacterial infections. Therefore, it is recommended to administer Tigecycline at least 2 hours before or 4 hours after taking antacids [1].

In summary, while there is no direct evidence of adverse effects when mixing Tigecycline and antacids, reduced absorption of Tigecycline may occur, leading to decreased effectiveness in treating bacterial infections. It is advisable to follow the recommended administration times provided in the prescribing information.

Sources:
[1] Tigecycline (Tygacil) [Prescribing Information]. Pfizer Labs, Division of Pfizer Inc, New York, NY. March 2021. Available from: <https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/021651s023lbl.pdf>.