See the DrugPatentWatch profile for methotrexate
Methotrexate is a medication commonly used in the treatment of various conditions in children, including rheumatoid arthritis, psoriasis, and certain types of cancer. While it can be effective in managing these conditions, it is important to be aware of potential side effects that may occur.
According to the sources provided, there are several side effects associated with methotrexate use in children. These can vary in severity and may require close monitoring by healthcare professionals.
One of the most common side effects is gastrointestinal symptoms, such as nausea, vomiting, and diarrhea. These symptoms can usually be managed by taking the medication with food or adjusting the dosage. Additionally, methotrexate can affect the liver, leading to elevated liver enzymes. Regular liver function tests are typically recommended to monitor for any potential liver damage.
Another potential side effect is bone marrow suppression, which can result in a decrease in red and white blood cell counts. This can increase the risk of infections and anemia. Regular blood tests are usually conducted to monitor blood cell counts and ensure the medication is not causing any significant suppression.
In rare cases, methotrexate can cause lung problems, such as interstitial pneumonitis. This can lead to symptoms such as cough, shortness of breath, and chest pain. If any of these symptoms occur, it is important to seek medical attention promptly.
Methotrexate can also affect the immune system, making individuals more susceptible to infections. It is important to take precautions to minimize the risk of infection, such as practicing good hygiene and avoiding contact with individuals who are sick.
It is worth noting that the benefits of methotrexate in managing the underlying condition often outweigh the potential side effects. However, it is crucial to closely monitor children who are taking this medication and report any concerning symptoms to their healthcare provider.
In conclusion, methotrexate can be an effective medication for various conditions in children, but it is important to be aware of potential side effects. These can include gastrointestinal symptoms, liver toxicity, bone marrow suppression, lung problems, and increased susceptibility to infections. Regular monitoring and close communication with healthcare professionals are essential to ensure the safe and effective use of this medication.
Sources:
[1] "Methotrexate." Drug Patent Watch.
[2] "10 Things Parents Should Know About Methotrexate." Arthritis Foundation.
[3] "Methotrexate in juvenile idiopathic arthritis: towards tailor-made treatment." Pediatric Rheumatology.