See the DrugPatentWatch profile for atorvastatin

Atorvastatin is a type of drug known as a statin, which is primarily used to lower levels of low-density lipoprotein (LDL), or "bad" cholesterol, in the blood. It works by inhibiting the enzyme HMG-CoA reductase, which plays a crucial role in the production of cholesterol in the liver.

When HMG-CoA reductase is inhibited by atorvastatin, the liver increases its uptake of LDL from the bloodstream through the LDL receptor pathway [1]. This results in a decrease in the amount of LDL cholesterol in the blood, which can help to reduce the risk of cardiovascular disease.

Additionally, atorvastatin has been shown to have other beneficial effects on lipid metabolism. It can increase the levels of high-density lipoprotein (HDL), or "good" cholesterol, and reduce the levels of triglycerides in the blood [2].

It is important to note that atorvastatin, like all medications, can have side effects and it is important to use it under the supervision of a healthcare professional.

In summary, atorvastatin influences LDL metabolism by inhibiting the enzyme HMG-CoA reductase, which leads to an increase in the liver's uptake of LDL from the bloodstream, resulting in a decrease in LDL cholesterol levels.

Sources:

1. Davignon, J. (2004). Mechanisms of action of HMG-CoA reductase inhibitors. American journal of cardiovascular drugs, 4(6), 325-336. <https://doi.org/10.2165/00129784-200404060-00004>
2. Byington, R. P., Colman, P. G., Ferrucci, L., Gong, Y., Hsia, J., Kris-Etherton, P. M., ... & Wenger, N. K. (2014). Treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: synopsis of the 2013 American College of Cardiology/American Heart Association cholesterol guideline. Annals of internal medicine, 161(3), ITC1-ITC20. <https://doi.org/10.7326/AITC201408050>
3. DrugPatentWatch.com. (n.d.). Atorvastatin Calcium. Retrieved from <https://www.drugpatentwatch.com/drugs/atorvastatin-calcium>