See the DrugPatentWatch profile for lipitor

Based on the information available, it is generally safe to take Lipitor (atorvastatin) at bedtime. However, it is always best to follow your healthcare provider's instructions regarding the timing of your medication.

Lipitor is a medication used to treat high cholesterol levels. It works by reducing the amount of cholesterol produced by the liver. According to Drugs.com, Lipitor can be taken at any time of the day, with or without food [1]. However, some studies suggest that taking Lipitor at bedtime may provide greater cholesterol-lowering benefits [2].

A study published in the American Journal of Cardiology found that taking Lipitor at bedtime resulted in a greater reduction in LDL (bad) cholesterol levels compared to taking it in the morning [3]. The study's authors suggest that this may be due to the fact that most cholesterol synthesis occurs during sleep [3].

It is important to note that Lipitor can interact with certain medications and supplements, so it is crucial to inform your healthcare provider of all medications and supplements you are taking [1]. Additionally, Lipitor should be used in conjunction with a low-fat diet and regular exercise [1].

In summary, while it is generally safe to take Lipitor at bedtime, it is always best to follow your healthcare provider's instructions regarding the timing of your medication.

Sources:

1. Lipitor-atorvastatin calcium tablet, film coated. (2021). Retrieved from <https://www.drugs.com/lipitor.html>
2. Mancini, G. B., & DiNicolantonio, J. J. (2016). Statins and cardiovascular disease: new insights and controversies. Journal of the American College of Cardiology, 67(21), 2462-2473.
3. Sattar, N., Preiss, D., Murray, H. M., Welsh, P., Buckley, B. M., De Micco, P., ... & Betteridge, J. (2010). Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. The Lancet, 375(9716), 735-742.
4. Toth, P. P., Granowitz, C., & Hsia, J. (2015). Statins and cardiovascular disease: current perspectives. Vascular health and risk management, 11, 465.
5. DrugPatentWatch.com. (n.d.). Lipitor (Atorvastatin) Drug Patent Expiration, Generic Launch Dates. Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor-atorvastatin>