See the DrugPatentWatch profile for lipitor

Based on the information available, there is limited research directly investigating the combined use of Lipitor (atorvastatin) and ACE inhibitors in relation to heightened side effects. However, both Lipitor and ACE inhibitors can have side effects when used independently [1].

Lipitor, a statin medication, is used to lower cholesterol levels and reduce the risk of heart attack and stroke [1]. Common side effects of Lipitor include headache, muscle and joint pain, and digestive issues such as diarrhea, constipation, and gas [1].

ACE (angiotensin-converting enzyme) inhibitors are a class of drugs used to treat hypertension and heart failure [2]. Some common side effects of ACE inhibitors include dry cough, dizziness, and headaches [2].

When combining Lipitor and ACE inhibitors, healthcare providers must consider the potential for drug interactions and increased side effects [3]. While there is no direct evidence suggesting that side effects are heightened when combining these two classes of drugs, it is essential to monitor patients closely for any adverse reactions [3].

In summary, while there is no direct evidence that side effects are heightened when combining Lipitor and ACE inhibitors, healthcare providers should closely monitor patients for potential adverse reactions due to the individual side effects associated with each medication.

Sources:

1. [Lipitor (atorvastatin) - Drug Patent Watch](https://www.drugpatentwatch.com/drugs/lipitor)
2. [ACE Inhibitors - Mayo Clinic](https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/in-depth/ace-inhibitors/art-20047750)
3. [Combining atorvastatin and ACE inhibitors in patients with hypertension and hyperlipidemia](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659773/)