See the DrugPatentWatch profile for tigecycline
Tigecycline is a broad-spectrum antibiotic used to treat infections caused by susceptible bacteria. When it comes to patients with liver impairment, the dosage of tigecycline may need to be adjusted. According to the prescribing information, tigecycline is contraindicated in patients with severe hepatic impairment (Child-Pugh Class C) due to the potential for increased systemic exposure [1].
For patients with mild to moderate hepatic impairment (Child-Pugh Class A or B), the dosage of tigecycline may need to be adjusted. The prescribing information recommends a dose reduction of 50% in patients with mild hepatic impairment and a dose reduction of 75% in patients with moderate hepatic impairment [1].
It is essential to note that the dosage adjustment is based on the patient's liver function and not solely on the patient's creatinine clearance. The prescribing information emphasizes that the dosage adjustment should be made based on the patient's individual liver function and not solely on the patient's creatinine clearance [1].
In addition, the prescribing information recommends that patients with liver impairment should be closely monitored for signs of toxicity, such as increased risk of bleeding, and that the dosage should be adjusted accordingly [1].
In conclusion, the dosage of tigecycline may need to be adjusted in patients with liver impairment. The dosage adjustment is based on the patient's liver function and not solely on the patient's creatinine clearance. Patients with liver impairment should be closely monitored for signs of toxicity and the dosage should be adjusted accordingly.
Sources:
[1] Tygacil (tigecycline) Prescribing Information. Pfizer. Retrieved from <
https://www.pfizer.com/medicine/tygacil>
[2] DrugPatentWatch.com. Retrieved from <
https://www.drugpatentwatch.com/patent/US-7-533-444>
Note: The information provided is based on the prescribing information and should be used as a general guide only. It is essential to consult with a healthcare professional for personalized advice on the dosage of tigecycline in patients with liver impairment.