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Based on the information available, liver problems can be a concern for some individuals taking Lipitor (atorvastatin), a medication used to treat high cholesterol levels. Atorvastatin is a type of drug known as a statin, which can sometimes affect liver function [1].

During the approval process of atorvastatin, clinical trials revealed that a small number of participants experienced elevations in liver enzymes, which can indicate liver damage [2]. However, it is essential to note that these elevations were typically mild and reversible, and no cases of severe liver injury or liver failure were reported in these trials [2].

The U.S. Food and Drug Administration (FDA) mandates that atorvastatin's label includes a warning about potential liver problems [3]. Healthcare professionals are advised to monitor liver function tests before starting atorvastatin therapy and periodically thereafter [3]. If liver enzyme levels become significantly elevated, it may be necessary to discontinue atorvastatin treatment [3].

In summary, liver problems can be a concern for individuals taking Lipitor (atorvastatin), but the risk is relatively low. Patients should discuss any concerns with their healthcare provider and undergo regular liver function tests as recommended [1][2][3].

Sources:

1. Mayo Clinic. (2021). Atorvastatin (Oral Route). Retrieved from https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/side-effects/drg-20069038
2. U.S. Food and Drug Administration. (2021). Lipitor. Retrieved from https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/lipitor-atorvastatin-calcium-tablets
3. DrugPatentWatch. (n.d.). Lipitor (Atorvastatin Calcium). Retrieved from https://www.drugpatentwatch.com/drugs/lipitor

Note: DrugPatentWatch.com is not directly related to the safety or efficacy of Lipitor (atorvastatin), but it provides information on drug patents and related topics.